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9:00 am - 9:20 am
Welcome to the 2020 Bay Area RNA Club Meeting
Michael McManusMichael McManus
9:20 am - 10:00 am
10:00 am - 10:13 am
10:13 am - 10:26 am
10:26 am - 10:39 am
10:40 am - 10:53 am
10:53 am - 11:06 am
11:06 am - 11:19 am
11:20 am - 11:33 am
11:33 am - 11:46 am
11:46 am - 11:59 am
12:00 pm - 1:00 pm
Careers in Industry I
Namita Bisaria, PhDSarah Denny, PhDCareers in Industry II
Hari Bhaskaran, PhDKristin Gleitsman, PhDAvantika Lal, PhDPhD to Postdoc I
Ami Bhatt, MD, PhDHani Goodarzi, PhDEric Lai, PhDPhD to Postdoc II
Le CongJeffrey Kieft, PhDMandy Muller, PhDPhD to Postdoc III
Leo Chou, PhDAstrid Haase, MD, PhDPostdoc to PI I
Susan Carpenter, PhDDaniel KimSelena Sagan, PhDPostdoc to PI II
Britt Glaunsinger, PhDPedro Miura, PhDStephanie Moon, PhDPostdoc to PI III
Gloria Brar, PhDBen Montpetit, PhDTodd Lowe, PhD
1:00 pm - 1:40 pm
A Strand Bias Assay to Detect Linear Extrachromosomal DNA (ecDNA)
A structured viral RNA uses molecular mimicry and conformational dynamics to coordinate multiple functions
Analysis of ARM-seq and DM-tRNA-seq using tRAX allows for detection of tissue-specific tRNA/tDRNA expression and modifications
Analysis of mRNP Complexes by Fluorescence Correlation and Cross-Correlation Spectroscopy
Chemically modified antisense guide oligonucleotides for Adenosine Deaminases acting on RNA (ADAR) editing of a Rett Syndrome target
CRISPRi-based genetic screen of functional long non-coding RNAs in Ewing Sarcoma
Detection of Alternative Isoforms of Gene Fusions Using Long-Read Nanopore RNA-seq
Diversity of RNA structures replicated by T7 DNA dependent RNA polymerase (DdRP)
Functional characterization of the RNA interference machinery of Aspergillus fumigatus
Gammaherpesviruses alter the tRNA expression landscape
Influence of circular target RNA topology on miRNA stability and function
MESA: A Tool for Comprehensive Splicing Quantification
Mitochondrial function governs Smaug MLO dissolution
Nucleotide-resolution Assessment of tRNAs and tRNA-derived small RNAs Across Mouse Tissues
One transcript, distinct stabilities: The methionine biosynthesis operon in Staphylococcus aureus
Polyspecific CRISPR approaches to unlock combination based therapies
Post-transcriptional regulation of a developmental EMT program is mediated by P-bodies
Spatial mapping of diverse gene signatures and cell type specific markers across mouse brain using the RNAscope™ HiPlexUp in situ hybridization assay.
Spatial profiling of highly homologous 3R and 4R Tau isoforms during mouse brain development using BaseScopeTM in situ hybridization technology
Step into the Unresolved: Versatile Tools Towards Real-time Single-molecule Biology
Understanding the contribution of somatic mutations in the splicing factor U2AF1 in the context of other driver mutations in lung cancer.
High-resolution view of HIV-1 Reverse Transcriptase initiation and its inhibition by NNRTI drugs
1:40 pm - 2:20 pm
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans
Characterization of tRNAs and tRNA-derived Small RNAs in Human Cerebral Cortical Organoids
Decoding the Mechanistic Principles of Gene Regulation by Mitochondrial 3D Spatial Organization
Engineering the retron reverse transcriptase to produce customizable ssDNA as a tool for synthetic biology
Establishment of a stoichiometry analysis method for characterizing mRNP composition by single molecule TIRF imaging
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants
Health and Disease Across Generations: Identification of endonucleases involved in the cleavage of Transfer RNA's in the male reproductive tract
Mechanism of transcriptional silencing by piRNAs
Mechanisms of Conserved RNA localization
Nucleotide resolution profiling of m3C RNA modification by HAC-seq
Pan-cancer, pervasive upregulation of 3’UTR splicing drives tumorigenesis
Potential tRNAs interfering with Pol2 transcription: VAC14
RNA binding protein IGF2BP1/IMP1 regulates translation of autophagy pathway genes
SARS-CoV2 novel transcript detection with SICILIAN identifies known and novel discontinuous splicing events
Single molecule dynamics of eIF4F-mediated mRNA cap recognition
Spatially-resolved high-plex in situ RNA expression profiling with NanoString GeoMx Whole Transcriptome Atlas
Statistical detection of splice sites that drive differential alternative splicing in single cells
Structure of the SARS-CoV-2 Nsp1/5′-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and Virulence
Systematic Characterization of Branchsite Mutations Perturbing RNA Splicing
TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical shells
The genomic Z score (GZS) detects changes in mRNA processing in single-cell data
Using CRISPR/Cas9 to Identify Oncogenic Splicing Events in Lung Adenocarcinoma
2:20 pm - 3:00 pm
A microRNA linking human positive selection and metabolic disorders
A moonlighting microRNA: human miR-122-mediated viral RNA accumulation and mechanism(s) of resistance to miR-122-based therapies
A rare codon-based translational program of cell proliferation
A small RNA-mediated feedback loop maintains proper levels of 22G-RNAs in C. elegans
A T1D-associated lncRNA modulates the type I interferon signaling and the antiviral response in pancreatic beta cells.
Applications of ribosome profiling (RIBO-seq) for high-resolution analysis of protein expression at proteome level.
Characterization of piRNA populations
Comprehensive sequence-to-function mapping of ligand-dependent RNA catalysis
Exploring the piRNA sequence space and the potential of piRNA-mediated silencing.
Functional implications of PIWI-interacting RNA (piRNA) diversity and abundance.
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells
Identifying a functional exosomal circLPAR1 as early diagnostic biomarkers of colorectal cancer
Interplay between miRNA precursors and biogenesis enzymes promotes a widespread increase of aberrant isoforms in tumors
Interrogating the role of ADAR1 in lung adenocarcinoma through identification of A-to-I editing in long reads
LABRAT reveals association of alternative polyadenylation with transcript localization, RBP expression, transcription speed, and cancer survival
METTL1-mediated m7G tRNA modification drives oncogenic transformation
Oncogenic circFAM120A promotes cognate mRNA translation in an IGF2BP2 dependent manner
RNA editing plays a primary role in common autoimmune diseases
Screening for functional circular RNAs using the CRISPR-Cas13 system
Site-Selective RNA Modification via DNA-induced Structure
The short and long-range RNA-RNA Interactome of SARS-CoV-2
Transcription polymerase–catalyzed emergence of novel RNA replicons
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation