Oral presentation
ribosomal translocation, ribosomes, ribosomal frameshifting, Translation, Translation elongation
Public Summary
Blocking GTP hydrolysis during ribosomal translocation abolishes reverse rotation of the 30S head domain. We propose that – rather than driving tRNA movement – GTP hydrolysis is used as a checkpoint to ensure productive translocation and strict maintenance of the translational reading frame.
Presenter
Gillian Rexroad
Graduate Student
Harry Noller, University of California, Santa Cruz