Oral presentation
Extracellular RNA, exosome, cancer, transposable elements, lncRNA, KRAS, KZNFs, RNA sequencing
Public Summary
Many human cancers are driven by mutant KRAS, but its effects on noncoding RNA are unclear. Reggiardo et al. show that mutant KRAS regulates this RNA landscape by silencing KRAB zinc-finger genes that normally repress transposable element noncoding RNAs, which are preferentially released from mutant KRAS cells in extracellular vesicles.
Presenter
Roman Reggiardo
Graduate Student
Daniel Kim, University of California, Santa Cruz
Other Attending Contributors
Daniel Kim, PhD
Lab Head
Daniel Kim, University of California, Santa Cruz
Sreelakshmi Velandi Maroli, PhD
Graduate Student
Daniel Kim, University of California, Santa Cruz