Irene Beusch, PhD
Postdoc
Hiten Madhani, University of California, San Francisco
Pronouns: she/her
During my postdoctoral work in the Madhani lab at UCSF, my research focuses on understanding the key contributors within the human spliceosome, which enable its tolerance for its broad target range despite a requirement for fidelity. To this purpose I have established a CRISPR-Cas9 base editing system in haploid human cells, which allows for high-throughput mutagenesis and screening of viable missense mutants to further our understanding of this essential cellular machine. During my PhD at ETH Zurich, I was interested in how RNA-binding proteins interact with their target sequences to influence splice site choice and splicing outcome. I studied their molecular interaction using NMR as well as other biochemical and biophysical methods.
My Presentations
Topics of Interest
- Bay Area RNA Conference
- RNA Mechanism
- RNA Technologies
- Sequence Exploration
- Gene Regulation
- Workshops, Sessions, and Socials
- Postdoc to PI